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Isaac (2), son of Isaac (1) Sheldon, was born in England. 1627, died at Windsor, Connecticut. July 27, 1708. He settled at Windsor and Northampton. He married (first) Mary, daughter of Thomas Woodford. She died April 17, 1684, and he married (second) Mehitable (Ensign) Gunn, divorced wife of Thomas Gunn, daughter of David Ensign. Children: Mary, born 1654; Isaac, September 4, 1656; John, December 5, 1658, mentioned elsewhere: Thomas, August 8. 1661; Ruth. (twin) August 27. 1663: Thankful, (twin) ; Mindwell, February 24, 1666; Joseph, February 1, 1668, died ill Boston ; Hannah, June 29, 1670: Eleazer, 1672. died young; Samuel. November 9. 1675; Ebenezer. March 1, 1677; Mercy, born and died February 24, 1681; Jonathan, May 29, 1687