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Isaac, son of Reuben Parmele, was born in Connecticut. 1799, died at West Bloomfield, Ontario county, New York, 1886, at an advanced age. During his childhood his parents removed to Ontario county, and the old homestead farm still remains in the possession of the family. He was an active factor in the upbuilding of the community in which he took up his abode, and his influence for good was felt throughout the entire section. He married Laura, daughter of Ebenezer Leach, of Lima, New York, and six children were born to them, among whom was Hiram Taft.