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James Witcher, of Virginia, married Martha Watson, and they had three sons and three daughters. Ephraim, their eldest son, who was a soldier in the war of 1812, settled in Montgomery Co., Mo., and married Winifred B. Holley, by whom he had six children. He died in 1845, and his widow married Col. Reuben Pew, who also died, leaving her a widow the second time.