The following data is extracted from A History of the Pioneer Families of Missouri - Montgomery County.
John Jacobs, of Germany, came to America and settled in Virginia, where he married Sarah Crawford. Their children were David, John, Peter, William, Elizabeth C., and Susan H. William married Margaret A., daughter of Daniel McDaniel and Mary Anderson, who were natives of Edinburgh, Scotland. By her he had Charles A., George R., Mary, Anna, Sallie, Sophia, and Catharine H. Mr. Jacobs died in Virginia in 1828, and in 1831 his widow removed to Missouri and settled in Montgomery County, where she died in 1850. Charles, who was a wealthy merchant of New Orleans, died without marrying. George R., who was a physician, married Louisa Parsons, of Virginia, and settled in Montgomery Co., Mo., in 1831, but subsequently removed to Boone County. Mary and Anna died single, in Montgomery County, one in 1843 and the other in 1844. Sophia married Dr. Gorge Y. Bast, of New Florence. Catharine H. married Henry Clark, Sr.
Source: A History of the Pioneer Families of Missouri - Montgomery County