The following data is extracted from A History of the Pioneer Families of Missouri - Warren County.
John Chambers, of Ireland, settled in North Carolina and married Mary Thompson, of Kentucky, by whom he had John, Jr., William, Sarah, James, Thomas, Alexander, Nancy, and Jane. In 1798 Mr. Chambers came to Missouri and settled in St. Louis County, and in 1800 his wife died. After that he lived with his son, Thomas, in St. Charles. Thomas married Eleanor Kennedy, and the names of their children were Prospect, Riley, Sarah, Julia, Harriet, Davis H., Ellen, Rhoda, and Thomas, Jr. Thomas and Alexander Chambers were rangers together in Captain Musick's company, and were at the battle of the sinkhole in (now) Lincoln County. Alexander married the widow of Frank McDermid, who was killed at Callaway's defeat. Her maiden name was Ruth Costlio. James, son of John Chambers, Sr., was a tanner and lived in (now) Warren County.
Source: A History of the Pioneer Families of Missouri - Warren County