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The subject of this sketch was born February, 1825, in Pope County, Arkansas, son of Jacob Hitchcock, of Massachusetts, and Nancy Brown, of East Hartford, Conn. Jacob Hitchcock, father to the subject of our sketch, settled among the Cherokees in 1820, and died in Lee County, Iowa, in July, 1865. Isaac, being a delicate boy, spent his youth at home, deriving most of his knowledge from reading and parental instruction. In 1847 he commenced teaching, and taught at Fort Smith for a short time, after which he attended Sequoyah national school for three sessions. Before the war Mr. Hitchcock taught in the Cherokee and Creek Nations, being associated with the Tallahassee Presbyterian Mission in 1854 and 1855. During the war he went north with his family, and afterward re-commenced teaching at Fort Gibson, and from thence taught at various points in the Cherokee Nation. Mr. Hitchcock during his lifetime has disseminated knowledge in the States of Kansas, Arkansas, Iowa, and Missouri. In 1857 he married Miss Eliza Ann Duncan, daughter of Rev. John Duncan, a leading Cherokee councilor. She was a graduate of the Cherokee High School, and a lady of accomplishments. By this marriage Mr. Hitchcock has two sons, T. B. Hitchcock and Iraeneus Hitchcock and a daughter named Etta, married to Mr. Samuel Burns. Mr. Hitchcock was teaching at the national male seminary when it closed last season. He is an excellent Cherokee scholar, and writes and sings in that language with great ease, but his chief business is literature, he being a correspondent for various papers and journals. Mr. Hitchcock intends to travel through the States next year with a band of Cherokee singers and lecture at various points.